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Article

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.

Oncotarget - 29 Sept 2015

Stout Michael B, Swindell William R, Zhi Xu, Rohde Kyle, List Edward O, Berryman Darlene E, Kopchick John J, Gesing Adam, Fang Yimin, Masternak Michal M

Abstract excerpt

Mice lacking the growth hormone receptor (GHRKO) exhibit improved lifespan and healthspan due to loss of growth hormone signaling. Both the distribution and activity of brown and white adipose tissue (BAT and WAT) are altered in GHRKO mice, but the contribution of each tissue to age-related phenotypes has remained unclear. We therefore used whole-genome microarrays to evaluate transcriptional differences in BAT...

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Identifiers

PMID: 26436954
DOI: 10.18632/oncotarget.5760
PMCID: PMC4694946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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