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Article

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

4 Aug 2016

Abstract excerpt

Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology are unclear. Here, we found that optineurin actively suppressed receptor-interacting kinase 1 (RIPK1)-dependent signaling by regulating its turnover. Loss of OPTN led to...

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PMID: 27493188
DOI: 10.1126/science.aaf6803

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