Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

24 Nov 2012

Abstract excerpt

Aggregation of misfolded proteins and the associated loss of neurons are considered a hallmark of numerous neurodegenerative diseases. Optineurin is present in protein inclusions observed in various neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's disease, Parkinson's disease, Creutzfeld-Jacob disease and Pick's disease. Optineurin deletion mutations have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23178947
DOI: 10.1242/jcs.114926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregatesPMID 23178947Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms.Semantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Semantic proximity Read ↗

Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosisSemantic proximity Read ↗

ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.Semantic proximity Read ↗

Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Semantic proximity Read ↗

A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.Semantic proximity Read ↗

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALSSemantic proximity Read ↗

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.Semantic proximity Read ↗

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.