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Article

Optineurin in neurodegenerative diseases

1 Feb 2011

Abstract excerpt

Optineurin is a gene associated with normal tension glaucoma and primary open-angle glaucoma, one of the major causes of irreversible bilateral blindness. Recently, mutations in the gene encoding optineurin were found in patients with amyotrophic lateral sclerosis (ALS). Immunohistochemical analysis showed aggregation of optineurin in skein-like inclusions and round hyaline inclusions in the spinal cord,...

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Identifiers

PMID: 21284751
DOI: 10.1111/j.1440-1789.2011.01199.x

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Related research

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Research trail→

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Optineurin in neurodegenerative diseasesPMID 21284751Read ↗

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Semantic proximity Read ↗

Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.Semantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Optineurin and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.Semantic proximity Read ↗

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregatesSemantic proximity Read ↗

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

Toward an integrative view of Optineurin functionsSemantic proximity Read ↗

Cellular Functions of Optineurin in Health and Disease.Semantic proximity Read ↗

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms.Semantic proximity Read ↗

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