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Article

Evaluation of polygenic risk scores for predicting breast and prostate cancer risk.

Genetic epidemiology - 1 Sept 2011

Machiela Mitchell J, Chen Chia-Yen, Chen Constance, Chanock Stephen J, Hunter David J, Kraft Peter

Abstract excerpt

Recently, polygenic risk scores (PRS) have been shown to be associated with certain complex diseases. The approach has been based on the contribution of counting multiple alleles associated with disease across independent loci, without requiring compelling evidence that every locus had already achieved definitive genome-wide statistical significance. Whether PRS assist in the prediction of risk of common cancers...

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Identifiers

PMID: 21618606
DOI: 10.1002/gepi.20600
PMCID: PMC4089860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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