Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.

PloS one - 27 Jan 2010

Guo Xuemin, Ernst Nancy Lewis, Carnes Jason, Stuart Kenneth D

Abstract excerpt

Most mitochondrial mRNAs in trypanosomes undergo uridine insertion/deletion editing that is catalyzed by approximately 20S editosomes. The editosome component KREPA3 is essential for editosome structural integrity and its two zinc finger (ZF) motifs are essential for editing in vivo but not in vi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondria
Share to Protozoan Proteins
Share to Reverse Transcriptase Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoproteins

Share to RNA Editing

Share to RNA, Messenger

Share to Trypanosoma brucei brucei

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 20111718
DOI: 10.1371/journal.pone.0008913
PMCID: PMC2811742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20111718-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.PMID 20111718Read ↗

Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.Semantic proximity Read ↗

The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.Semantic proximity Read ↗

Multiple domains of the integral KREPA3 protein are critical for the structure and precise functions of RNA editing catalytic complexes in Trypanosoma brucei.Semantic proximity Read ↗

RNA editing in Trypanosoma brucei requires three different editosomes.Semantic proximity Read ↗

Trypanosome RNA editing: the complexity of getting U in and taking U outSemantic proximity Read ↗

KREPA6 functions in RNA editing catalytic complex structural organization and gRNA utilization in Trypanosoma brucei.Semantic proximity Read ↗

Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex.Semantic proximity Read ↗

Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editingSemantic proximity Read ↗

RNA editing: complexity and complicationsSemantic proximity Read ↗

Comparative analysis of editosome proteins in trypanosomatidsSemantic proximity Read ↗

TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei.Semantic proximity Read ↗

Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed ‘bifunctional’ gRNA in mRNA A6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.