Article
Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex.
Molecular cell - 1 Aug 2003
Schnaufer Achim, Ernst Nancy Lewis, Palazzo Setareh S, O'Rear Jeff, Salavati Reza, Stuart Kenneth
Abstract excerpt
The Trypanosoma brucei editosome catalyzes the maturation of mitochondrial mRNAs through the insertion and deletion of uridylates and contains at least 16 stably associated proteins. We examined physical and functional associations among these proteins using three different approaches: purification of complexes via tagged editing ligases TbREL1 and TbREL2, comprehensive yeast two-hybrid analysis, and...
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