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Article

APOL1 toxin, innate immunity, and kidney injury.

Kidney international - 1 Jul 2015

Limou Sophie, Dummer Patrick D, Nelson George W, Kopp Jeffrey B, Winkler Cheryl A

Abstract excerpt

The discovery that two common APOL1 alleles were strongly associated with nondiabetic kidney diseases in African descent populations led to hope for improved diagnosis and treatment. Unfortunately, we still do not have a clear understanding of the biological function played by APOL1 in podocytes or other kidney cells, nor how the renal risk alleles initiate the development of nephropathies. Important clues for...

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Source

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Identifiers

PMID: 25853332
DOI: 10.1038/ki.2015.109
PMCID: PMC4490079

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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