Article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Nature genetics - 1 Sept 2016
Zhou Kaixin, Yee Sook Wah, Seiser Eric L, van Leeuwen Nienke, Tavendale Roger, Bennett Amanda J, Groves Christopher J, Coleman Ruth L, van der Heijden Amber A, Beulens Joline W, de Keyser Catherine E, Zaharenko Linda, Rotroff Daniel M, Out Mattijs, Jablonski Kathleen A, Chen Ling, Javorský Martin, Židzik Jozef, Levin Albert M, Williams L Keoki, Dujic Tanja, Semiz Sabina, Kubo Michiaki, Chien Huan-Chieh, Maeda Shiro, Witte John S, Wu Longyang, Tkáč Ivan, Kooy Adriaan, van Schaik Ron H N, Stehouwer Coen D A, Logie Lisa, Sutherland Calum, Klovins Janis, Pirags Valdis, Hofman Albert, Stricker Bruno H, Motsinger-Reif Alison A, Wagner Michael J, Innocenti Federico, 't Hart Leen M, Holman Rury R, McCarthy Mark I, Hedderson Monique M, Palmer Colin N A, Florez Jose C, Giacomini Kathleen M, Pearson Ewan R
Abstract excerpt
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was...
Read the complete abstract on PubMed