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Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations

1 Jul 2023

Abstract excerpt

Objectives To compare associations between the Gilbert syndrome genotype in European populations, measured bilirubin concentrations, genetically predicted bilirubin using this genotype, and a wide range of health outcomes in a large cohort. Design Cohort study including observational, genetic, and Mendelian randomisation analyses. Setting 22 centres across England, Scotland, and Wales in UK Biobank (2006-10),...

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PMID: 37456363
DOI: 10.1136/bmjmed-2022-000467

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