Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort.

Journal of hepatology - 1 Dec 2014

Horsfall Laura J, Hardy Rebecca, Wong Andrew, Kuh Diana, Swallow Dallas M

Abstract excerpt

BACKGROUND & AIMS: Bilirubin has potent antioxidant properties in vitro and raised serum levels have been associated with lower rates of respiratory disease. The enzyme uridine diphosphate glucuronosyltransferase polypeptide 1A1 (UGT1A1) is solely responsible for clearing bilirubin from the blood and homozygosity for seven thymine-adenine (TA) repeats in the TATA box regulatory element of the UGT1A1 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bilirubin
Share to Forced Expiratory Volume

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gilbert Disease

Share to Glucuronosyltransferase

Share to Lung Diseases

Share to Pulmonary Disease, Chronic Obstructive

Share to Respiratory Function Tests

Share to Vital Capacity

Source

Identifiers

PMID: 25086287
DOI: 10.1016/j.jhep.2014.07.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort.PMID 25086287Read ↗

Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associationsSemantic proximity Read ↗

Molecular genetic basis of Gilbert's syndrome.Semantic proximity Read ↗

UGT1A1*28 Genotypes and Respiratory Disease in Very Preterm Infants: A Cohort Study.Semantic proximity Read ↗

Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects.Semantic proximity Read ↗

UDP-glucuronosyltransferase 1A1 (UGT1A1) gene haplotypes and their effect on serum bilirubin concentration in healthy Indian adults.Semantic proximity Read ↗

Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn.Semantic proximity Read ↗

Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study.Semantic proximity Read ↗

Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias.Semantic proximity Read ↗

Serum bilirubin concentration in healthy adult North-Europeans is strictly controlled by the UGT1A1 TA-repeat variants.Semantic proximity Read ↗

Genome-wide association meta-analysis for total serum bilirubin levels.Semantic proximity Read ↗

Identifying Potential Therapeutic Applications and Diagnostic Harms of Increased Bilirubin Concentrations: A Clinical and Genetic Approach.Semantic proximity Read ↗

UGT1A1 gene polymorphisms in North Indian neonates presenting with unconjugated hyperbilirubinemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.