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Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study.

Cells - 15 Feb 2021

Seyed Khoei Nazlisadat, Carreras-Torres Robert, Murphy Neil, Gunter Marc J, Brennan Paul, Smith-Byrne Karl, Mariosa Daniela, Mckay James, O'Mara Tracy A, Jarrett Ruth, Hjalgrim Henrik, Smedby Karin E, Cozen Wendy, Onel Kenan, Diepstra Arjan, Wagner Karl-Heinz, Freisling Heinz

Abstract excerpt

Bilirubin, an endogenous antioxidant, may play a protective role in cancer development. We applied two-sample Mendelian randomization to investigate whether genetically raised bilirubin levels are causally associated with the risk of ten cancers (pancreas, kidney, endometrium, ovary, breast, prostate, lung, Hodgkin's lymphoma, melanoma, and neuroblastoma). The number of cases and their matched controls of...

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Identifiers

PMID: 33671849
DOI: 10.3390/cells10020394
PMCID: PMC7918902

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