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Article

Identifying Potential Therapeutic Applications and Diagnostic Harms of Increased Bilirubin Concentrations: A Clinical and Genetic Approach.

Clinical pharmacology and therapeutics - 1 Feb 2022

Zanussi Jacy T, Zhao Juan, Dorn Chad A, Liu Ge, Feng QiPing, Wei WeiQi, Mosley Jonathan D, Stein C Michael, Kawai Vivian K

Abstract excerpt

Bilirubin has antioxidant and anti-inflammatory properties in vitro and in animal studies and protects against inflammatory, cardiovascular, and other diseases in observational studies; therefore, bilirubin has potential as a therapeutic agent. However, observational studies could be confounded by many factors. We used a genetic (n = 61,281) and clinical (n = 234,670) approach to define the association between...

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Identifiers

PMID: 34625956
DOI: 10.1002/cpt.2441
PMCID: PMC8748314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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