Article

Genome-wide association study reveals loci with sex-specific effects on plasma bile acids

2022-12-19

Abstract excerpt

Bile acids are essential for food digestion and nutrient absorption, but also act as signalling molecules involved in hepatobiliary diseases, gastrointestinal disorders and carcinogenesis. While many studies have focused on the genetic determinants of blood metabolites, research focusing specifically on genetic regulation of bile acids in the general population is currently lacking. Here we investigate the genetic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6861ce70-92a0-5cac-a360-f1e9ad181466
DOI: 10.1101/2022.12.16.22283452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study reveals loci with sex-specific effects on plasma bile acidsDOI 10.1101/2022.12.16.22283452Read

Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.Semantic proximity Read

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean PopulationSemantic proximity Read

The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population.Semantic proximity Read

Shared and Distinct Genetic Factors Underlying Bile Acid Regulation and Intrahepatic Cholestasis of Pregnancy.Semantic proximity Read

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysisSemantic proximity Read

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaSemantic proximity Read

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseasesSemantic proximity Read

Whole-exome sequencing reveals ANO8 as a genetic risk factor for intrahepatic cholestasis of pregnancySemantic proximity Read

Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associationsSemantic proximity Read

Genetic variations of bile salt transporters.Semantic proximity Read

Genome-wide association meta-analysis yields 20 loci associated with gallstone diseaseSemantic proximity Read

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.Semantic proximity Read