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Article

Interpreting elevated liver blood test results through a genetic lens: A genome-wide association study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2024

Innes Hamish, Buch Stephan, Kendall Timothy J, Fallowfield Jonathan A, Guha Indra Neil

Abstract excerpt

BACKGROUND AND AIMS: Individuals with genetic polymorphisms in UGT1A1 exhibit bilirubin levels that belie their risk of liver disease (Gilbert's syndrome) but it is not known if this phenomenon extends to other common liver blood tests (LBTs). METHODS: A genome-wide association analysis of 10 LBTs was conducted using the UK biobank. Polygenic scores (PGS) were created from discordant loci (e.g. loci associated...

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Bilirubin
gamma-Glutamyltransferase
Gilbert Disease
Glucuronosyltransferase
Liver Cirrhosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Function Tests

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Identifiers

PMID: 39425533
DOI: 10.1111/liv.16114
PMCID: PMC11586890

Genes

UGT1A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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