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Article

The Origin, Differentiation, and Functions of Cancer-Associated Fibroblasts in Gastrointestinal Cancer

1 Jan 2023

Abstract excerpt

Emerging evidence has shown the importance of the tumor microenvironment in tumorigenesis and progression. Cancer-associated fibroblasts (CAFs) are one of the most infiltrated stroma cells of the tumor microenvironment in gastrointestinal tumors. CAFs play crucial roles in tumor development and therapeutic response by biologically secreting soluble factors or structurally remodeling the extracellular matrix....

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Identifiers

PMID: 37451403
DOI: 10.1016/j.jcmgh.2023.07.001

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