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Article

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2021

Mahajan Mukesh, Bharambe Nikhil, Shang Yutong, Lu Bin, Mandal Abhishek, Madan Mohan Pooja, Wang Rihua, Boatz Jennifer C, Manuel Martinez Galvez Juan, Shnyrova Anna V, Qi Xin, Buck Matthias, van der Wel Patrick C A, Ramachandran Rajesh

Abstract excerpt

Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion. Emerging evidence suggests that a direct yet unresolved interaction of the mechanoenzymatic GTPase dynamin-related protein 1 (Drp1) with mitochondrial outer membrane-localized cardiolipin (CL), externalized under stress conditions including mitophagy, catalyzes essential mitochondrial hyperfragmentation. Here, using a...

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Identifiers

PMID: 34261790
DOI: 10.1073/pnas.2023079118
PMCID: PMC8307854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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