Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells.

EMBO reports - 6 Sept 2023

Yahia Yousra, Pigeot Alexia, El Aabidine Amal Zine, Shah Nilay, Karasu Nezih, Forné Ignasi, Krebs Stefan, Blum Helmut, Esnault Cyril, Sexton Tom, Imhof Axel, Eick Dirk, Andrau Jean-Christophe

Abstract excerpt

The largest subunit of RNA polymerase (Pol) II harbors an evolutionarily conserved C-terminal domain (CTD), composed of heptapeptide repeats, central to the transcriptional process. Here, we analyze the transcriptional phenotypes of a CTD-Δ5 mutant that carries a large CTD truncation in human cells. Our data show that this mutant can transcribe genes in living cells but displays a pervasive phenotype with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphorylation

Share to RNA Polymerase II

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 37424514
DOI: 10.15252/embr.202256150
PMCID: PMC10481650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells.PMID 37424514Read ↗

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals.Semantic proximity Read ↗

RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.Semantic proximity Read ↗

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation.Semantic proximity Read ↗

High-resolution mapping of human RNA polymerase III reveals transcription termination as a rate-limiting stepSemantic proximity Read ↗

Widespread occurrence of non-canonical transcription termination by human RNA polymerase IIISemantic proximity Read ↗

Phosphorylation of the RNA polymerase II C-terminal domain dictates transcription termination choice.Semantic proximity Read ↗

Human RNA polymerase III termination favors decomposition over facilitated recycling.Semantic proximity Read ↗

Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.Semantic proximity Read ↗

The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription.Semantic proximity Read ↗

The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.Semantic proximity Read ↗

A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3' end processing.Semantic proximity Read ↗

Unique features of transcription termination and initiation at closely spaced tandem human genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.