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Article

The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription.

eLife - 26 Aug 2020

Hildreth A Elizabeth, Ellison Mitchell A, Francette Alex M, Seraly Julia M, Lotka Lauren M, Arndt Karen M

Abstract excerpt

Compared to other stages in the RNA polymerase II transcription cycle, the role of chromatin in transcription termination is poorly understood. We performed a genetic screen in Saccharomyces cerevisiae to identify histone mutants that exhibit transcriptional readthrough of terminators. Amino acid substitutions identified by the screen map to the nucleosome DNA entry-exit site. The strongest H3 mutants revealed...

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PMID: 32845241
DOI: 10.7554/eLife.57757
PMCID: PMC7449698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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