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Widespread occurrence of non-canonical transcription termination by human RNA polymerase III

17 Mar 2011

Abstract excerpt

Human RNA polymerase (Pol) III-transcribed genes are thought to share a simple termination signal constituted by four or more consecutive thymidine residues in the coding DNA strand, just downstream of the RNA 3'-end sequence. We found that a large set of human tRNA genes (tDNAs) do not display any T(≥4) stretch within 50 bp of 3'-flanking region. In vitro analysis of tDNAs with a distanced T(≥4) revealed the...

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PMID: 21421562
DOI: 10.1093/nar/gkr074

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