Article
RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.
Genes & development - 1 Dec 1991
Liao S M, Taylor I C, Kingston R E, Young R A
Abstract excerpt
The largest subunit of RNA polymerase II contains a unique carboxy-terminal domain (CTD) that consists of repeats of the heptapeptide YSPTSPS. RNA polymerase II CTD truncation mutations affect the ability to induce transcription of a subset of yeast genes in vivo, and the lack of response to induction maps to the upstream activating sequences of these genes. Here, we report that progressive truncation of the...
Topics
- Amino Acid Sequence
- Base Sequence
- Molecular Sequence Data
- Mutation
- Nucleosomes
- Protein Conformation
- RNA Polymerase II
- Saccharomyces cerevisiae
- Trans-Activators
- Transcription, Genetic