Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.

doi:10.1093/molbev/msq151

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Article

Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.

Molecular biology and evolution - 1 Nov 2010

Liu Pengda, Kenney John M, Stiller John W, Greenleaf Arno L

Abstract excerpt

With a simple tandem iterated sequence, the carboxyl terminal domain (CTD) of eukaryotic RNA polymerase II (RNAP II) serves as the central coordinator of mRNA synthesis by harmonizing a diversity of sequential interactions with transcription and processing factors. Despite intense research interest, many key questions regarding functional and evolutionary constraints on the CTD remain unanswered; for example,...

Topics

Amino Acid Sequence
Circular Dichroism
Conserved Sequence
Evolution, Molecular
Genetic Variation
Models, Genetic
Molecular Sequence Data
Mutagenesis, Insertional
Mutant Proteins
Peptides
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Pliability

Protein Structure, Tertiary

RNA Polymerase II

Saccharomyces cerevisiae

Structure-Activity Relationship

Source

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Identifiers

PMID: 20558594
DOI: 10.1093/molbev/msq151
PMCID: PMC2981489

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