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Article

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes.

Molecular brain - 27 Jan 2021

Shin Sangyep, Santi Andrea, Huang Shiyong

Abstract excerpt

Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory neurons to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors in mice with conditional Pten knockout in parvalbumin (PV)-expressing or somatostatin...

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Identifiers

PMID: 33504340
DOI: 10.1186/s13041-021-00731-8
PMCID: PMC7839207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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