Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes.

Neuroscience research - 1 Jul 2010

Sadakata Tetsushi, Furuichi Teiichi

Abstract excerpt

Ca(2+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) regulates dense-core vesicle (DCV) exocytosis. We found that CAPS2 is involved in the secretion of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and that CAPS2 KO mice not only have deficits in neuronal development and survival but also exhibit abnormal behaviors, including impaired social interaction, hyperactivity, an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autistic Disorder
Share to Behavior, Animal
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mice, Knockout

Share to Nerve Growth Factors

Share to Nerve Tissue Proteins

Source

Identifiers

PMID: 20302894
DOI: 10.1016/j.neures.2010.03.006

Genes

CAPS2
BDNF
CADPS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes.PMID 20302894Read ↗

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.Semantic proximity Read ↗

Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants.Semantic proximity Read ↗

Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice.Semantic proximity Read ↗

Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2‐neo mouse rescued by L‐type calcium channel blockersSemantic proximity Read ↗

ASTN2 in ASD and neurodevelopmental disorders.Semantic proximity Read ↗

CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.Semantic proximity Read ↗

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.Semantic proximity Read ↗

Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.