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Article

Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant.

Redox biology - 1 Aug 2023

Roveri Antonella, Di Giacinto Flavio, Rossetto Monica, Cozza Giorgio, Cheng Qing, Miotto Giovanni, Zennaro Lucio, Di Paolo Maria Luisa, Arnér Elias S J, De Spirito Marco, Maiorino Matilde, Ursini Fulvio

Abstract excerpt

The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD). Wild-type and mutated recombinant enzymes with selenopcysteine (Sec) at the active site, were purified and structurally characterized to investigate the impact of the...

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Identifiers

PMID: 37413766
DOI: 10.1016/j.redox.2023.102806
PMCID: PMC10345155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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