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GPX4: old lessons, new features

27 Jun 2022

Abstract excerpt

GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell...

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PMID: 35758268
DOI: 10.1042/bst20220682

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