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Article

The proportion of Met80-sulfoxide dictates peroxidase activity of human cytochrome c.

Dalton transactions (Cambridge, England : 2003) - 10 Jul 2018

Parakra Rinky D, Kleffmann Torsten, Jameson Guy N L, Ledgerwood Elizabeth C

Abstract excerpt

The peroxidase activity of cytochrome c is proposed to contribute to apoptosis by peroxidation of cardiolipin in the mitochondrial inner membrane. However, cytochrome c heme is hexa-coordinate with a methionine (Met80) on the distal side, stopping it from acting as an efficient peroxidase. The first naturally occurring variant of cytochrome c discovered, G41S, has higher peroxidase activity than wild-type. To...

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PMID: 29944150
DOI: 10.1039/c8dt02185f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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