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Article

Contribution of selenocysteine to the peroxidase activity of selenoprotein S.

Biochemistry - 20 Aug 2013

Liu Jun, Rozovsky Sharon

Abstract excerpt

Selenoprotein S (SelS, VIMP) is an intrinsically disordered enzyme that utilizes selenocysteine to catalyze the reduction of disulfide bonds and peroxides. Here it is demonstrated that selenocysteine is the residue oxidized by the peroxide substrate. It is possible to trap the reaction intermediate selenenic acid when the resolving cysteine is mutated. The selenocysteine allows SelS to rapidly re-form its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23914919
DOI: 10.1021/bi400741c
PMCID: PMC3809988

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