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Article

Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms.

The FEBS journal - 1 Feb 2018

Brandstaedter Christina, Fritz-Wolf Karin, Weder Stine, Fischer Marina, Hecker Beate, Rahlfs Stefan, Becker Katja

Abstract excerpt

In most cells, the thioredoxin (Trx) and glutathione systems are essential in maintaining redox homeostasis. The selenoprotein thioredoxin glutathione reductase (TGR) is a hybrid enzyme in which a glutaredoxin (Grx) domain is linked to a thioredoxin reductase (TrxR). Notably, the protein is also capable of reducing glutathione disulfide (GSSG), thus representing an important link between the two redox systems. In...

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PMID: 29222842
DOI: 10.1111/febs.14357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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