Article
Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins.
Nature communications - 7 Apr 2020
Liedgens Linda, Zimmermann Jannik, Wäschenbach Lucas, Geissel Fabian, Laporte Hugo, Gohlke Holger, Morgan Bruce, Deponte Marcel
Abstract excerpt
Class I glutaredoxins are enzymatically active, glutathione-dependent oxidoreductases, whilst class II glutaredoxins are typically enzymatically inactive, Fe-S cluster-binding proteins. Enzymatically active glutaredoxins harbor both a glutathione-scaffold site for reacting with glutathionylated disulfide substrates and a glutathione-activator site for reacting with reduced glutathione. Here, using yeast ScGrx7 as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.