Article
Inter- and intra-tumor heterogeneity of genetic and immune profiles in inherited renal cell carcinoma.
Cell reports - 25 Jul 2023
Tabata Mariko, Sato Yusuke, Kogure Yasunori, McClure Marni B, Oshikawa-Kumade Yuji, Saito Yuki, Shingaki Sumito, Ito Yuta, Yuasa Mitsuhiro, Koya Junji, Yoshida Kazushi, Kohno Takashi, Miyama Yu, Morikawa Teppei, Chiba Kenichi, Okada Ai, Ogawa Seishi, Ushiku Tetsuo, Shiraishi Yuichi, Kume Haruki, Kataoka Keisuke
Abstract excerpt
Patients with von Hippel-Lindau disease (vHL) are at risk of developing spatially and temporally multiple clear cell renal cell carcinomas (ccRCCs), which offers a valuable opportunity to analyze inter- and intra-tumor heterogeneity of genetic and immune profiles within the same patient. Here, we perform whole-exome and RNA sequencing, digital gene expression, and immunohistochemical analyses for 81 samples from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.