Article

Spatiotemporal evolution of the ccRCC microenvironment links intra-tumoral heterogeneity to immune escape

2022-07-13

Abstract excerpt

<h4>Background</h4> Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here we seek to elucidate how ITH and tumor evolution during immune checkpoint inhibitor (ICI) treatment can lead to therapy resistance. <h4>Methods</h4> Here, we spatiotemporally profiled the genomic and immunophenotypic characte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33bef075-9d66-5188-baca-e9b3f495f41a
DOI: 10.1101/2022.07.11.22277322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal evolution of the ccRCC microenvironment links intra-tumoral heterogeneity to immune escapeDOI 10.1101/2022.07.11.22277322Read

Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escapeSemantic proximity Read

High intratumoral heterogeneity in clear cell renal cell carcinoma is associated with reduced immune response and survivalSemantic proximity Read

High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpointsSemantic proximity Read

Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneitySemantic proximity Read

Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune MicroenvironmentSemantic proximity Read

Inter- and intra-tumor heterogeneity of genetic and immune profiles in inherited renal cell carcinoma.Semantic proximity Read

Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancerSemantic proximity Read

Multimodal cell communication networks nominate immunotherapies for RCC subgroups with discrete T cell recruitment or expansionSemantic proximity Read

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy responseSemantic proximity Read

Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinomaSemantic proximity Read

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor TherapySemantic proximity Read

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.Semantic proximity Read