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Article

Klotho Gene Expression Is Decreased in Peripheral Blood Mononuclear Cells in Patients with Alzheimer's Disease and Frontotemporal Dementia.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Sorrentino Federica, Fenoglio Chiara, Sacchi Luca, Serpente Maria, Arighi Andrea, Carandini Tiziana, Arosio Beatrice, Ferri Evelyn, Arcaro Marina, Visconte Caterina, Rotondo Emanuela, Scarpini Elio, Galimberti Daniela

Abstract excerpt

BACKGROUND: The longevity gene Klotho (KL) was recently associated with neurodegenerative diseases including Alzheimer's disease (AD). Its role in the brain has not been completely elucidated, although evidence suggests that KL-VS heterozygosity is associated with a reduced risk of AD in Apolipoprotein E ɛ4 carriers. Conversely, no data about genetic association with frontotemporal dementia (FTD) are available so...

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PMID: 37393504
DOI: 10.3233/JAD-230322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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