Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atypical White Matter Hyperintensities Markedly Impact Plasma Neurofilament Light Chain Variability in GRN Patients.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Vítor Joana, Saracino Dario, Ströer Sebastian, Camuzat Agnès, Dorgham Karim, Clot Fabienne, Martin-Hardy Philippe, Pasquier Florence, Le Ber Isabelle

Abstract excerpt

GRN mutations, causing frontotemporal dementia, can be associated with atypical white matter hyperintensities (WMH). We hypothesized that the presence of WMH may impact neurofilament light chain (NfL) levels, markers of neuroaxonal damage. We analyzed plasma NfL in 20 GRN patients and studied their association to visually-scored WMH burden. The 12 patients displaying atypical WMH had significantly higher NfL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Frontotemporal Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intermediate Filaments

Share to Mutation

Share to Neurofilament Proteins

Share to Progranulins

Share to White Matter

Source

Identifiers

PMID: 37393503
DOI: 10.3233/JAD-230315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atypical White Matter Hyperintensities Markedly Impact Plasma Neurofilament Light Chain Variability in GRN Patients.PMID 37393503Read ↗

White Matter Hyperintensities Precede other Biomarkers in <i>GRN</i> Frontotemporal DementiaSemantic proximity Read ↗

White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study.Semantic proximity Read ↗

White matter hyperintensities characterize monogenic frontotemporal dementia with granulin mutations.Semantic proximity Read ↗

Plasma Neurofilament Light Chain and Clinical Diagnosis in Frontotemporal Dementia SyndromesSemantic proximity Read ↗

Neurofilament light chain: a biomarker for genetic frontotemporal dementiaSemantic proximity Read ↗

Extensive White Matter Involvement in Patients With Frontotemporal Lobar DegenerationSemantic proximity Read ↗

White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohortSemantic proximity Read ↗

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.Semantic proximity Read ↗

Plasma neurofilament light chain is elevated in Niemann-Pick Type C but glial fibrillary acidic protein is notSemantic proximity Read ↗

Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disordersSemantic proximity Read ↗

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics.Semantic proximity Read ↗

The role of neurofilament light in genetic frontotemporal lobar degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.