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The role of neurofilament light in genetic frontotemporal lobar degeneration

26 Nov 2022

Abstract excerpt

Abstract Genetic frontotemporal lobar degeneration caused by autosomal dominant gene mutations provides an opportunity for targeted drug development in a highly complex and clinically heterogeneous dementia. These neurodegenerative disorders can affect adults in their middle years, progress quickly relative to other dementias, are uniformly fatal and have no approved disease-modifying treatments. Frontotemporal...

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PMID: 36694576
DOI: 10.1093/braincomms/fcac310

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