Article
CLPTM1L is a GPI-anchoring pathway component targeted by HCMV.
The Journal of cell biology - 4 Sept 2023
Kol Inbal, Rishiq Ahmed, Cohen Mevaseret, Kahlon Shira, Pick Ophir, Dassa Liat, Stein Natan, Bar-On Yotam, Wolf Dana G, Seidel Einat, Mandelboim Ofer
Abstract excerpt
The GPI-anchoring pathway plays important roles in normal development and immune modulation. MHC Class I Polypeptide-related Sequence A (MICA) is a stress-induced ligand, downregulated by human cytomegalovirus (HCMV) to escape immune recognition. Its most prevalent allele, MICA*008, is GPI-anchored via an uncharacterized pathway. Here, we identify cleft lip and palate transmembrane protein 1-like protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.