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Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit.

Molecules (Basel, Switzerland) - 8 Sept 2021

Liu Si-Si, Jin Fei, Liu Yi-Shi, Murakami Yoshiko, Sugita Yukihiko, Kato Takayuki, Gao Xiao-Dong, Kinoshita Taroh, Hattori Motoyuki, Fujita Morihisa

Abstract excerpt

Glycosylphosphatidylinositol (GPI) anchor modification is a posttranslational modification of proteins that has been conserved in eukaryotes. The biosynthesis and transfer of GPI to proteins are carried out in the endoplasmic reticulum. Attachment of GPI to proteins is mediated by the GPI-transamidase (GPI-TA) complex, which recognizes and cleaves the C-terminal GPI attachment signal of precursor proteins. Then,...

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PMID: 34576938
DOI: 10.3390/molecules26185462
PMCID: PMC8465894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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