Article
A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008.
The Biochemical journal - 1 Sept 2013
Ashiru Omodele, López-Cobo Sheila, Fernández-Messina Lola, Pontes-Quero Samuel, Pandolfi Rachele, Reyburn Hugh T, Valés-Gómez Mar
Abstract excerpt
The human MICA (MHC I-related chain A) gene, encoding a ligand for the NKG2D (NKG2-D type II integral membrane protein) receptor, is highly polymorphic. A group of MICA alleles, named MICA 5.1 (prototype, MICA*008), produce a truncated protein due to a nucleotide insertion in the transmembrane domain. These alleles are very frequent in all of the human populations studied and they have different biological...
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