Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

24 Apr 2023

Abstract excerpt

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we present a comprehensive transcriptomic and epigenomic map of disease-relevant blood immune cell subsets from AS patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Spondyloarthritis Studies and Treatments

Source

Identifiers

PMID: 37388915
DOI: 10.1016/j.xgen.2023.100306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitisPMID 37388915Read ↗

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.Semantic proximity Read ↗

Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitisSemantic proximity Read ↗

Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitisSemantic proximity Read ↗

Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associationsSemantic proximity Read ↗

Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.Semantic proximity Read ↗

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease riskSemantic proximity Read ↗

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid ArthritisSemantic proximity Read ↗

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read ↗

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritisSemantic proximity Read ↗

Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic lociSemantic proximity Read ↗

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis.Semantic proximity Read ↗

Progress of genome‐wide association studies of ankylosing spondylitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.