Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations

30 Apr 2016

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA), our ability to translate these results into disease understanding and novel therapeutics is limited. Most RA GWAS loci reside outside of protein-coding regions and likely affect distal transcriptional enhancers. Furthermore, GWAS do not identify the cell types where the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Rheumatoid Arthritis Research and Therapies
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27140173
DOI: 10.1186/s13059-016-0948-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associationsPMID 27140173Read ↗

Genetics of rheumatoid arthritis contributes to biology and drug discovery.Semantic proximity Read ↗

CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.Semantic proximity Read ↗

Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.Semantic proximity Read ↗

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitisSemantic proximity Read ↗

Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.Semantic proximity Read ↗

Integrative analyses for functional mechanisms underlying associations for rheumatoid arthritis.Semantic proximity Read ↗

Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis.Semantic proximity Read ↗

Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis.Semantic proximity Read ↗

Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4+ T cells through differential DNA methylation, explaining a substantial proportion of heritability.Semantic proximity Read ↗

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.Semantic proximity Read ↗

[Genome-wide association study for rheumatoid arthritis].Semantic proximity Read ↗

Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.