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Article

β-Catenin regulates endocardial cushion growth by suppressing p21.

Life science alliance - 1 Sept 2023

Liu Huahua, Lu Pengfei, He Shan, Luo Yuru, Fang Yuan, Benkaci Sonia, Wu Bingruo, Wang Yidong, Zhou Bin

Abstract excerpt

Endocardial cushion formation is essential for heart valve development and heart chamber separation. Abnormal endocardial cushion formation often causes congenital heart defects. β-Catenin is known to be essential for endocardial cushion formation; however, the underlying cellular and molecular mechanisms remain incompletely understood. Here, we show that endothelial-specific deletion of β-catenin in mice...

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Identifiers

PMID: 37385754
DOI: 10.26508/lsa.202302163
PMCID: PMC10310929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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