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Article

The Wnt/beta-catenin pathway regulates cardiac valve formation.

Nature - 9 Oct 2003

Hurlstone Adam F L, Haramis Anna-Pavlina G, Wienholds Erno, Begthel Harry, Korving Jeroen, Van Eeden Fredericus, Cuppen Edwin, Zivkovic Danica, Plasterk Ronald H A, Clevers Hans

Abstract excerpt

Truncation of the tumour suppressor adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin signalling pathway. Apc has a role in development: for example, embryos of mice with truncated Apc do not complete gastrulation. To understand this role more fully, we examined the effect of truncated Apc on zebrafish development. Here we show that, in contrast to mice, zebrafish do complete...

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PMID: 14534590
DOI: 10.1038/nature02028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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