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Article

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors.

Development (Cambridge, England) - 1 Jun 2012

Acharya Asha, Baek Seung Tae, Huang Guo, Eskiocak Banu, Goetsch Sean, Sung Caroline Y, Banfi Serena, Sauer Marion F, Olsen Gregory S, Duffield Jeremy S, Olson Eric N, Tallquist Michelle D

Abstract excerpt

The basic helix-loop-helix (bHLH) family of transcription factors orchestrates cell-fate specification, commitment and differentiation in multiple cell lineages during development. Here, we describe the role of a bHLH transcription factor, Tcf21 (epicardin/Pod1/capsulin), in specification of the cardiac fibroblast lineage. In the developing heart, the epicardium constitutes the primary source of progenitor cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial-Mesenchymal Transition

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Identifiers

PMID: 22573622
DOI: 10.1242/dev.079970
PMCID: PMC3357908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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