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Article

Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus.

Antimicrobial agents and chemotherapy - 18 Jul 2023

Martínez-González Brenda, Gallego Isabel, Gregori Josep, Soria María Eugenia, Somovilla Pilar, de Ávila Ana Isabel, García-Crespo Carlos, Durán-Pastor Antoni, Briones Carlos, Gómez Jordi, Quer Josep, Domingo Esteban, Perales Celia

Abstract excerpt

The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the present study, we report the mild mutagen activity of sofosbuvir (SOF) for hepatitis C virus (HCV). Serial passages of HCV in human hepatoma cells, in the presence of SOF at a concentration well below its cytotoxic concentration 50...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37367486
DOI: 10.1128/aac.00394-23
PMCID: PMC10353389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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