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Article

Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy.

Gastroenterology - 1 Mar 2007

Hofmann Wolf Peter, Polta Andreas, Herrmann Eva, Mihm Ulrike, Kronenberger Bernd, Sonntag Tanja, Lohmann Volker, Schönberger Barbara, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND AND AIMS: Addition of ribavirin to interferon alfa treatment has substantially increased sustained virologic response rates in patients with chronic hepatitis C (CHC). Ribavirin acts as an RNA virus mutagen in vitro, thereby leading to error catastrophe. However, data in CHC are controversial. METHODS: The nonstructural (NS) 5B quasi-species heterogeneity was analyzed in Huh7 cells harboring a...

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Identifiers

PMID: 17383421
DOI: 10.1053/j.gastro.2006.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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