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Article

Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients.

Journal of virology - 1 Jun 2013

Dietz Julia, Schelhorn Sven-Eric, Fitting Daniel, Mihm Ulrike, Susser Simone, Welker Martin-Walter, Füller Caterina, Däumer Martin, Teuber Gerlinde, Wedemeyer Heiner, Berg Thomas, Lengauer Thomas, Zeuzem Stefan, Herrmann Eva, Sarrazin Christoph

Abstract excerpt

The preeminent mode of action of the broad-spectrum antiviral nucleoside ribavirin in the therapy of chronic hepatitis C is currently unresolved. Particularly under contest are possible mutagenic effects of ribavirin that may lead to viral extinction by lethal mutagenesis of the hepatitis C virus...

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Source

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Identifiers

PMID: 23536652
DOI: 10.1128/JVI.02778-12
PMCID: PMC3648094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23536652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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