Article
Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin.
Antimicrobial agents and chemotherapy - 24 Jan 2023
Somovilla Pilar, García-Crespo Carlos, Martínez-González Brenda, Soria María Eugenia, de Ávila Ana Isabel, Gallego Isabel, Mínguez Pablo, Durán-Pastor Antoni, Ferrer-Orta Cristina, Salar-Vidal Llanos, Esteban-Muñoz Mario, Zuñiga Sonia, Sola Isabel, Enjuanes Luis, Esteban Jaime, Fernandez-Roblas Ricardo, Gadea Ignacio, Gómez Jordi, Verdaguer Nuria, Domingo Esteban, Perales Celia
Abstract excerpt
We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant spectrum of SARS-CoV-2 replicating in the absence or presence of ribavirin indicated an increase in the number of mutations, but not in deletions, and modification of diversity indices, expected from a mutagenic activity. Notably,...
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