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Article

Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus.

Antimicrobial agents and chemotherapy - 1 Jun 2016

Gallego Isabel, Sheldon Julie, Moreno Elena, Gregori Josep, Quer Josep, Esteban Juan Ignacio, Rice Charles M, Domingo Esteban, Perales Celia

Abstract excerpt

Sofosbuvir displays a high phenotypic barrier to resistance, and it is a component of several combination therapies for hepatitis C virus (HCV) infections. HCV fitness can be a determinant of decreased sensitivity to direct-acting antiviral agents such as telaprevir or daclatasvir, but fitness-dependent decreased drug sensitivity has not been established for drugs with a high phenotypic barrier to resistance....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27067341
DOI: 10.1128/AAC.00581-16
PMCID: PMC4879421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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