Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.

PloS one - 1 Jan 2016

de Ávila Ana I, Gallego Isabel, Soria Maria Eugenia, Gregori Josep, Quer Josep, Esteban Juan Ignacio, Rice Charles M, Domingo Esteban, Perales Celia

Abstract excerpt

Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagen. Here we show that favipiravir (T-705) is a potent mutagenic agent for hepatitis C virus (HCV) during its replication in human hepatoma cells. T-705 leads to an excess of G → A and C → U transitions in the mutant spectrum of preextinction HCV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amides
Share to Antiviral Agents
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Pyrazines

Share to RNA, Viral

Share to Sequence Analysis, RNA

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 27755573
DOI: 10.1371/journal.pone.0164691
PMCID: PMC5068784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.PMID 27755573Read ↗

Extinction of Hepatitis C Virus by Ribavirin in Hepatoma Cells Involves Lethal MutagenesisSemantic proximity Read ↗

Lethal Mutagenesis of Rift Valley Fever Virus Induced by FavipiravirSemantic proximity Read ↗

Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus.Semantic proximity Read ↗

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.Semantic proximity Read ↗

Resistance of high fitness hepatitis C virus to lethal mutagenesis.Semantic proximity Read ↗

T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In VitroSemantic proximity Read ↗

Genome-Wide Mutagenesis of Hepatitis C Virus Reveals Ability of Genome To Overcome Detrimental Mutations.Semantic proximity Read ↗

Favipiravir elicits antiviral mutagenesis during virus replication in vivoSemantic proximity Read ↗

Back to the future: revisiting HIV-1 lethal mutagenesis.Semantic proximity Read ↗

Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo.Semantic proximity Read ↗

Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model.Semantic proximity Read ↗

Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.