Article
Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity.
Protein science : a publication of the Protein Society - 1 Aug 2023
Buratti Fiamma A, Fernández Claudio Oscar, Zweckstetter Markus
Abstract excerpt
Parkinson's disease can manifest either as a sporadic form, which is common, or as an inherited autosomal dominant trait resulting from missense mutations. Recently, the novel α-synuclein variant V15A was identified in two Caucasian and two Japanese families with Parkinson's disease. Using a combination of NMR spectroscopy, membrane binding assays and aggregation assays we show that the V15A mutation does not...
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